Singapore · Australia Trade Mission 2026
Beyond
the Tumor
Acoustic Biomarkers & Digital Interventions
in Precision Psycho-Oncology
Serena Cheng  ·  Sales Manager
竹謙科技 BambooDD
www.bamboodd.com
Voice Biomarkers AI Emotion Engine
30–50%
Cancer patients with clinically significant distress
70%
Distress reduction in oncology RCT (n=50)
349
Healthcare professionals in published validation study
The Clinical Gap
Distress as a Biological Accelerator
Psychological stress doesn't just affect quality of life — it actively fuels tumour progression at the molecular level.
30 –50%
of cancer patients experience
severe anxiety & depression
⚠️ The Clinical Reality
Clinics lack the tools for continuous emotional monitoring between appointments. Distress goes undetected — and biologically unaddressed.
📋
Questionnaires miss real-time distress changes
⏰
Clinic appointments too infrequent to monitor
STRESS → TUMOUR PROGRESSION CASCADE
🧠
Psychological Stress
↓
HPA Axis & SNS Activation
Sympathetic nervous system fires
↓
↑ Cortisol & Norepinephrine
Sustained hormonal cascade
↓
β2-Adrenergic Receptor Activation
↓
⚡
Promotes Tumour Growth
↑ VEGF Angiogenesis · M2-TAM polarization · T-cell exhaustion
CH₂C=O OHO Cortisol Structure
Cortisol — The Molecular Bridge
Sustained cortisol elevation activates the β2-AR pathway — the direct molecular link between emotional distress and tumour microenvironment changes: VEGF angiogenesis, M2-TAM polarization, and T-cell exhaustion.
Digital Therapeutics
Closed-Loop Intervention System
Detection automatically triggers the right therapeutic response at the right acuity level
HIGH DISTRESS DETECTED 🎙️ 🧠 🪷 🚨 SCREEN TREAT MONITOR SOS
BambooDD Yangyang
🧠
CBT Module
Targets catastrophic thinking patterns. Reverses CTRA gene expression — down-regulates IL-6, up-regulates anti-viral immunity.
🪷
Mindfulness Module
Down-regulates ANS. Lowers cortisol & LF/HF ratio — achieves parasympathetic dominance and immunological recovery.
🚨
Safety Escalation
Automated risk detection with human-in-the-loop handoff to clinical SOS services for acute crisis cases.
CTRA GENE EXPRESSION CHANGES
⬇️ IL-6 inflammation
⬇️ CTRA stress genes
⬆️ Anti-viral immunity
DNA LEVEL ILLUSTRATION
Safety & Clinical Ethics
Safety Net & Crisis Routing
Core Policy: We are not doctors. We do not diagnose. We do not replace clinical treatment.
CRISIS DETECTION FLOW
⚠️
Voice Emotion Analysis & NLP Suicide Keyword Detection
Running passively in the background every session
Immediate UI Pop-up
System checks in with patient
✅
"I'm Fine"
Session continues normally
🆘
Needs Help
→ 24/7 Lifeline
Zero Diagnostic Liability
Maximum patient safety. The system supports — never replaces — human clinical care.
REGULATORY POSITION
✓Wellness tool — not a medical device
✓No diagnosis issued to patients
✓Human-in-the-loop for all escalations
Clinical Study I — Oncology RCT
TPEVGH Randomised Controlled Trial
First oncology RCT for voice-based psycho-oncology intervention in Asia — completed December 2025
📋
Publication Status: Under Review
Full report completed December 2025. Currently undergoing peer-review process. International journal publication anticipated 2026.
INSTITUTION
TAIPEI VGH n = 50 oncology patients · RCT
Taipei Veterans General Hospital
n = 50 oncology patients · Randomised design
INTERVENTION
🗓️
3 Months
Voice AI monitoring + Digital CBT / Mindfulness combined protocol
PRIMARY OUTCOME
70%
Reduction in severe anxiety, depression & poor sleep
p < 0.001
DISTRESS SCORE — 3-MONTH TRAJECTORY
0 75 Distress p < 0.001 Baseline Month 1 Month 2 Month 3
📌 Clinical Significance
Statistically significant reduction across anxiety, depression and sleep quality in an active oncology cohort — all measures p < 0.001.
⏳ Publication Timeline
Report completed December 2025. Peer review in progress. International journal publication expected 2026.
Clinical Study II — Published Validation · PLOS ONE 2025
Voice Emotion AI: Peer-Reviewed Validation
Reliability & validity established in a real-world healthcare workforce cohort — published in PLOS ONE, 2025
✅
Published: PLOS ONE (2025)
349 nurses · Shuang Ho Hospital, Taipei Medical University · n=13,075 audio segments from 6,457 individuals · All results p < .001
APP vs. GOLD-STANDARD SCALES — VALIDITY CORRELATIONS
All p < .001
Emotion Gold-Standard Scale Pearson r Strength
😢 Sadness Beck Depression Inventory (BDI-II)
r = .47
Moderate
😊 Happiness Oxford Happiness Questionnaire (OHQ)
r = .45
Moderate
😠 Anger Novaco Anger Scale (NAS)
r = .42
Moderate
😨 Fear Perceived Stress Scale (PSS)
r = .41
Moderate
349
Nurses validated
(Shuang Ho Hospital)
13,075
Audio segments from
6,457 individuals
ICC 0.75–0.80
Test-retest reliability
(Good to Excellent)
~70%
AI model accuracy
on independent test set
💡
Why This Study Matters for Cancer Centres
Most competing AI emotion tools carry no peer-reviewed validation. BambooDD has published evidence — and the validation cohort of high-stress healthcare workers closely mirrors the oncology nursing and clinical psychology teams your centre employs.
All correlation coefficients statistically robust (p < .001) and all ICC values meet the "Good" reliability threshold — these are not chance findings.
Platform Architecture
Voice Emotion Analytics — 3-Tier Capability
One validated core engine. Three clinical intervention tiers across multiple care settings.
APPLICATIONS 🎗️ Oncology 🤱 Maternal Health 👴 Geriatric Care 📞 Crisis Lines CORE ENGINE Voice AI Analysis Voice Emotion Analysis · Acoustic Features · Neural Network Risk Scoring NLP Suicide Keyword Detection · Longitudinal Biomarker Tracking PLOS ONE Validated · ICC 0.75–0.80 · ~70% AI Accuracy OUTPUTS ✦ Emotion Risk Score ✦ CBT / Mindfulness ✦ Real-time Alerts ⚠ SOS Routing
🛡️
Prevention
Mindfulness & CBT tools for routine low-acuity emotional regulation.
Routine Care
📡
Intervention
Real-time risk flags — medical-grade stratification via voice biomarkers.
Mid-Acuity Alert
🚨
Crisis Response
NLP suicide detection — Human-in-the-Loop protocols for acute risk escalation.
High-Acuity SOS
Strategic Partnership
Integration with IMH Mindline 1771
Converting crisis detection into a national safety net for Singapore's mental health system
📱
User Call /
App Session
→
🎙️
Voice Emotion
Analytics
Real-time
→
🚨
Acute Risk
Detected
→
📋
Mindline
Triage
→
🤝
Counsellor
Intervention
Strategic Target
IMH & Mindline 1771
Singapore's national psychiatric institution and crisis helpline.
Value Delivered
Digital Extension
Continuous passive monitoring for high-risk callers between human sessions.
Operational Impact
Reduce Burnout
Automates routine emotional screening — frees counsellors for highest-acuity cases.
System Architecture
Closed-Loop Clinical Ecosystem
Unlike standalone wellness apps — includes a clinical "Safety Valve" bridging the liability gap between digital screening and human care
DETECT
Passive Voice Biomarkers
TREAT
Digital CBT & Mindfulness
INTERVENE
Human-in-the-Loop Handoff
MONITOR
Longitudinal Risk Engine
🔑 Key Differentiator
Most apps stop at DETECT. BambooDD bridges the liability gap by automating the handoff to SOS or clinical teams.
The only system with a built-in clinical safety valve.
🏥 Hospital / AIC Integration
Feeds validated risk data directly into hospital EMR and AIC systems — no new clinical workflows required.
Long-Term Outcomes
Sustained Efficacy & Neural Plasticity
Benefits persist 3 months after stopping the app — evidence of genuine neurological rewiring, not temporary effect
POST-INTERVENTION DISTRESS TRACKING
0 100 Distress Intervention Post-Intervention Baseline Month 3 Month 4 Month 6
📈 Long-Term Impact
3 months after stopping the app — neural pathway changes and low distress levels are maintained.
🧬 Neurological Context
Mitigates "Chemo-brain" microstate rigidity (Microstate D). Delivers durable ANS regulation — counteracts chronic stress-induced immunosuppression.
EEG Microstates A B C D A B C D ✓
Microstate D Stabilisation
Chemo-brain causes rigidity in EEG Microstate D — linked to cognitive flexibility. The intervention restores healthy microstate dynamics for durable autonomic regulation.
Target Markets — Singapore & Australia
Expanding Into High-Priority Mental Health Systems
BambooDD as an integration module — embedding directly into existing national mental health programmes and hospital workflows
🇸🇬
Singapore Mental Health Landscape
NATIONAL BLUEPRINT
Singapore's National Mental Health & Well-being Strategy 2023–2027 prioritises community-based, technology-enabled mental health services and early intervention.
KEY INSTITUTIONS & PROGRAMMES
🏥 IMH / Woodbridge Hospital — national psychiatric centre
📞 Mindline 1771 — 24/7 mental health crisis helpline
💻 Mindline.sg — digital mental wellness portal
🏢 Agency for Integrated Care (AIC) — community care integration
ALIGNMENT OPPORTUNITY
Seamlessly integrates with Mindline 1771 and AIC digital health streams. Supports Singapore's push towards continuous, data-driven community mental health monitoring.
🇦🇺
Australia Mental Health Landscape
NATIONAL STRATEGY
National Mental Health and Suicide Prevention Plan 2021–2031 — Australia's landmark 10-year commitment to digital and community-based mental health integration.
KEY FUNDING & INSTITUTIONS
🔬 NHMRC / MRFF — primary research grant bodies
🏥 Primary Health Networks (PHNs) — commission local mental health services
💻 Digital Mental Health Framework (ADHA) — digital health integration standards
📋 Medicare Better Access — mental health treatment plan rebates
ALIGNMENT OPPORTUNITY
Strong fit for NHMRC/MRFF co-grant applications, PHN digital health commissioning, and hospital oncology programme integration. 350+ validated professionals.
🏛️
Pilot
Government Services
Integrate into existing government-funded services for feasibility and outcomes evaluation.
🔬
Research
Hospitals & Universities
Co-develop IRB protocols & jointly apply for NHMRC / MRFF / NRF grants.
🔗
Integration
API / System Integrators
API-level integration into telehealth, aged-care, or robotics platforms via PHNs.
Value Proposition
Value Generation for Your Cancer Centre
Three mutually reinforcing pillars that transform clinical capability, operational efficiency and research output
PILLAR 1
Holistic Patient Care
Elevates your centre to a benchmark of Digital Holistic Care.
24/7 out-patient psychological support — zero additional headcount required.
PILLAR 2
Staff Efficiency
Reduces emotional labour burden on oncology nurses and social workers.
Routine tracking automated — staff focus their energy on complex cases only.
PILLAR 3
Academic Excellence
Continuous Acoustic Biomarker vs. Prognosis datasets for your researchers.
Powers high-impact publications — JCO, Lancet Oncology.
❌ TYPICAL WELLNESS APP
Detection only · No clinical escalation · No gene-level evidence · No RCT · Not peer-reviewed
✅ BAMBOODD
Full closed-loop · PLOS ONE published · RCT completed · Safety valve · CTRA gene-level · 349 validated
About Us
竹謙科技 BambooDD
Bridging the gap between mental health science and clinical-grade AI — built in Taiwan, deploying globally
BambooDD Company
🌿
竹謙科技 BambooDD
Precision mental health technology rooted in rigorous clinical validation
CORE TECHNOLOGY
🎙️ Voice Emotion AI — passive, objective emotional state monitoring
🧠 Digital CBT & Mindfulness — clinically validated therapeutic modules
🚨 NLP Crisis Detection — real-time keyword and emotion risk routing
📊 Longitudinal Risk Engine — continuous biomarker tracking
CLINICAL EVIDENCE
✅ PLOS ONE (2025) — 349 nurses, ICC 0.75–0.80, r up to .47
📋 TPEVGH RCT — 70% distress reduction, n=50, p<.001 (under review)
👥 350+ healthcare professionals validated across institutions
DEPLOYMENT & PARTNERSHIPS
🪖 Taiwan Military — 120,000 personnel · mental health monitoring programme
🏥 Government — Military, hospital etc. in Taiwan and Japan
🌏 Active trade expansion to Singapore & Australia (2026)
🔗 Integration-first architecture — API, EMR-compatible
Next Steps & Call to Action
Pioneering Precision Psycho-Oncology
Proposal: Initiate a targeted Pilot Program or Joint IRB Research Protocol — Singapore · Australia
PHASE 1
Sub-Specialty Selection
Identify target oncology cohort for the pilot programme.
🎗️ Breast
🫁 Lung
🧬 Haematology
→
PHASE 2
Deployment
Baseline acoustic biomarker mapping & digital intervention rollout. Co-author NHMRC / MRFF / NRF grant applications.
The Ask
Which oncology sub-specialty best aligns with your centre's current
strategic research and patient care goals?
🤝
Pilot Programme
Integrate into existing services for outcome evaluation — aligned with government health grant funding.
📑
Joint IRB Research
Co-develop IRB protocol & apply for NHMRC / MRFF / NRF research grants together.
Serena Cheng
Serena Cheng  ·  Sales Manager
📧
🌐 www.bamboodd.com  ·  竹謙科技 BambooDD
🇸🇬 Singapore
🇦🇺 Australia
Trade Mission 2026
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